Catalytic Dynamic Resolution Applied to the Synthesis of 2,6-disubstituted Piperidines: Preparation of (+)-lupetidine and (-)-epidihydropinidine.


The diastereoselective synthesis of trans-2,6-disubstituted piperidines has been rendered enantioselective by incorporating a catalytic dynamic resolution into the first alkylation step. The method has been applied to the synthesis of (-)-epidihydropinidine and (+)-trans-lupetidine.


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